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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Center: Imaging autism biomarkers + risk genes

Principal Investigator

Principal Investigator

Glatt, Stephen

Description

Description

This grant provides support for an NIH Autism Center of Excellence (ACE). This project is one of four that are part of the University of California, San Diego ACE. One major goal of this study is to identify, in postmortem brain tissue, distinct gene expression profiles of autism that can implicate risk genes for this highly heritable disorder. This will include validating some suspected risk genes for autism (e.g., genes in the apoptosis, neurogenesis, and Drosophila wingless homolog [wnf] pathways), as well as finding new candidate genes by observing patterns of expression of the entire human transcriptome in eight distinct brain regions. A second major goal is to identify, in circulating blood cells, a validated gene expression profile of autism that can be developed as a diagnostic tool to improve its identification and early treatment. The identification of risk genes for autism should facilitate the development of novel therapeutics, while the eventual development of a biological marker system for autism would greatly enhance the efficiency of current diagnostic methods, and it likely would facilitate the search for additional etiologic factors in the disorder.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

219925

Current Award Period

Current Award Period

2007-2012

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

3O. Not specific to Question 3 objectives

Project Link

Project Link

ACE Center: Imaging autism biomarkers + risk genes (External web link)

Institution

Institution

University of California, San Diego

State/Country

State/Country

California

Project Number

Project Number

5P50MH081755-04

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

ACE Center: Imaging autism biomarkers + risk genes | 201934 | 2009 | 5P50MH081755-03

 
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