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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Finding autism genes by genomic copy number analysis

Principal Investigator

Principal Investigator

Walsh, Christopher

Description

Description

Autism is a disorder that is likely caused by the interaction of genetic predispositions and environmental triggers that coalesce during a sensitive period of development to lead to the spectrum of behaviors known as autism spectrum disorder (ASD). In this project, researchers will examine 1) altered gene expression that may permit early identification of affected or at-risk children, 2) gene copy number analyses in ASD biological samples, 3) molecular mechanisms underlying the autism, 4) imaging results from typical and ASD brain during visual face processing, and 5) treatment regimens within the context of altered gene expression or neural function. The investigators in this application also aim to continue their collaborative effort that has produced and enhanced a highly successful open data and biomaterials resource for the research community, the Autism Genetic Resource Exchange (AGRE). This collaborative network application, involving six research sites and AGRE, will systematically and comprehensively investigate the genetics of ASD to identify rare mutations, chromosomal abnormalities, and common variation contributing to ASD susceptibility.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

582867

Current Award Period

Current Award Period

2007-2012

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.

Project Link

Project Link

Finding autism genes by genomic copy number analysis (External web link)

Institution

Institution

Children's Hospital Boston

State/Country

State/Country

Massachusetts

Project Number

Project Number

5R01MH083565-04

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Finding autism genes by genomic copy number analysis | 574507 | 2009 | 5R01MH083565-03
Finding autism genes by genomic copy number analysis | 557773 | 2008 | R01MH083565-02

 
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