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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Immunobiology in autism

Principal Investigator

Principal Investigator

Van de Water, Judy

Description

Description

Growing evidence points to a role for the immune system in autism. One possibility is that certain antibodies made by a pregnant mother can target her developing fetus in such a way as to increase autism risk. By this hypothesis, the antibodies are autoantibodies, which mistake the developing fetus as a foreign pathogen. Research from Dr. Van de Water's lab has found evidence for maternal autoantibodies that target fetal brain tissue in mothers of children with autism. Dr. Van de Water's fellow will further explore the role of these antibodies in autism and will begin to characterize the specific targets of these antibodies. First, the protein targets of antibodies from mothers of multiple children with autism multiplex will be compared to those from mothers of one child with autism simplex. This will reveal whether these are different types of autism that are associated with different maternal autoantibodies. Second, the location of the targeted proteins in the brain will be determined via immunohistochemistry. This technique will use the autoantibodies as markers; once bound to their targeted proteins in the brain, they will be visualized to reveal where in the brain the targeted proteins reside.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2008-2010

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SE. Support at least two studies to determine if there are subpopulations that are more susceptible to environmental exposures (e.g., immune challenges related to infections, vaccinations, or underlying autoimmune problems) by 2012. IACC Recommended Budget: $8,000,000 over 2 years.

Project Link

Project Link

Immunobiology in autism (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

2176

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Immunobiology in autism | 32000 | 2009 | 2176
Immunobiology in autism | 32000 | 2008 | 2176

 
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