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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Genetic and immunological risk factors for autism

Principal Investigator

Principal Investigator

Gregersen, Peter

Description

Description

This grant supports the collection of clinical data and associated biological samples, which will enable a broad based effort to identify genetic and immunological factors that cause autism and related neurodevelopmental disorders. Specific aim 1 will address the hypothesis that de novo genetic changes occur in autistic subjects, meaning that the duplication or deletion is not found in the genome of either parent but develop in the DNA of germ cells (egg or sperm) over the life of one parent. The researchers also hypothesize that these de novo changes can be causative when present in a permissive genetic background. Specific aim 2 will address the hypothesis that antibodies circulating in the mothers of autistic individuals can play a role in the development of autism as a result of exposure of the fetus to such antibodies during development in the uterus.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

423

Current Award Period

Current Award Period

2010-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SE. Support at least two studies to determine if there are subpopulations that are more susceptible to environmental exposures (e.g., immune challenges related to infections, vaccinations, or underlying autoimmune problems) by 2012. IACC Recommended Budget: $8,000,000 over 2 years.

Project Link

Project Link

Genetic and immunological risk factors for autism (External web link)

Institution

Institution

Feinstein Institute For Medical Research

State/Country

State/Country

New York

Project Number

Project Number

5M01RR018535-08

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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