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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Early exposure to acetaminophen and autism

Principal Investigator

Principal Investigator

Hertz-Picciotto, Irva

Description

Description

The proposed project will serve as a pilot study to assess feasibility of conducting a full investigation of whether intake of acetaminophen or other analgesics in early childhood is a risk factor for autism/ASD. Both the pilot and, if appropriate, the full study, will take advantage of data that have been generated from The CHARGE (Childhood Autism Risks from Genetics and the Environment) Study, an ongoing NIEHS-funded population based case-control study of children with autism or ASD, children with developmental delay but neither autism nor ASD, and typically developing controls recruited from the general population. For the pilot study, we will focus on a subset of cases of autism or ASD and a similar subset of typically developing controls and their early childhood medical information, including infections, fever, and use of acetaminophen, aspirin, and ibuprofen. Sources of data on intake of these medications and on their indications are primarily the maternal reports and pediatric records. These will be supplemented by product information to capture the wide range of over-the-counter treatments that may contain acetaminophen, aspirin or ibuprofen as an adjunct ingredient. The pilot study will evaluate the feasibility of obtaining a relatively comprehensive picture of exposures. In the full study, prevalence odds ratios will be calculated for each of these exposures in logistic regression models adjusting appropriately for sociodemographic, medical, and other potentially confounding variables.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

19997

Current Award Period

Current Award Period

2010-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.

Project Link

Project Link

Early exposure to acetaminophen and autism (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

7489

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Early exposure to acetaminophen and autism | 0 | 2011 | 7489

 
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