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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Effect of oxytocin receptor inhibitor (atosiban) during the perinatal period and prevalence of autism spectrum disorders

Principal Investigator

Principal Investigator

Ebstein, Richard

Description

Description

Among environmental factors that may confer risk for autism, perinatal factors are prominent. Based on multiple lines of research, it has been hypothesized that activity of the hormone oxytocin – a 'social' hormone that mediates affiliative behaviors in many species including humans – may be a perinatal factor that impacts the risk of autism spectrum disorders (ASD). This study will take an epidemiological approach to determining the roles of Pitocin and Atosiban in ASD. Dr. Ebstein and colleagues will recruit mother and child pairs from four categories: mothers having received Atosiban during pregnancy; mothers having received Nifedipine, a drug used to prevent preterm labor that does not affect oxytocin signaling; mothers that received Pitocin during labor; and a matched control group of mothers who received no drugs and delivered at term. Children of these mothers will be screened for neurodevelopmental delays, and those testing positive will undergo further evaluations for ASD.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

122950

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SH. Support at least three studies of special populations or use existing databases to inform our understanding of environmental risk factors for ASD in pregnancy and the early postnatal period by 2012. Such studies could include: o Comparisons of populations differing in geography, gender, ethnic background, exposure history (e.g., prematurity, maternal infection, nutritional deficiencies, toxins), and migration patterns; and o Comparisons of phenotype (e.g., cytokine profiles), in children with and without a history of autistic regression, adverse events following immunization (such as fever and seizures), and mitochondrial impairment. These studies may also include comparisons of phenotype between children with regressive ASD and their siblings. oEmphasis on environmental factors that influence prenatal and early postnatal development is particularly of high priority. Epidemiological studies should pay special attention to include racially and ethnically diverse populations. IACC Recommended Budget: $12,000,000 over 5 years.

Project Link

Project Link

Effect of oxytocin receptor inhibitor (atosiban) during the perinatal period and prevalence of autism spectrum disorders (External web link)

Institution

Institution

Hebrew University

State/Country

State/Country

Israel

Project Number

Project Number

2499

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Effect of oxytocin receptor inhibitor (Atosiban) during the perinatal period and prevalence of autism spectrum disorders | 150000 | 2008 | 2499
Effect of oxytocin receptor inhibitor (atosiban) during the perinatal period and prevalence of autism spectrum disorders | 131871 | 2009 | 2499
Effect of oxytocin receptor inhibitor (atosiban) during the perinatal period and prevalence of autism spectrum disorders | 105443 | 2011 | 2499

 
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