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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Structural and functional neural correlates of early postnatal deprivation

Principal Investigator

Principal Investigator

Behen, Michael

Description

Description

This is a Clinical Investigator Award, providing an opportunity for a medical investigator to develop into an independent researcher. Despite links between early postnatal deprivation (ESD) and neuropsychological problems, few studies have investigated whether the neural substrates thought to underlie such functions are abnormal in children with such histories. The overarching aim of the proposed studies is to probe, with imaging techniques, the structural and functional neurobiological consequences of ESD. The approach of integrating magnetic resonance imaging (MRI) and positron emission tomography (PET) methods with neuropsychological assessments is innovative and will yield new and important data on children exposed to ESD. These studies have potential translational value, as neuroimaging data can be used to monitor effects of therapeutic interventions and to assess the potential reversibility of findings, which has not been possible in the past.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

150412

Current Award Period

Current Award Period

2007-2012

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SH. Support at least three studies of special populations or use existing databases to inform our understanding of environmental risk factors for ASD in pregnancy and the early postnatal period by 2012. Such studies could include: o Comparisons of populations differing in geography, gender, ethnic background, exposure history (e.g., prematurity, maternal infection, nutritional deficiencies, toxins), and migration patterns; and o Comparisons of phenotype (e.g., cytokine profiles), in children with and without a history of autistic regression, adverse events following immunization (such as fever and seizures), and mitochondrial impairment. These studies may also include comparisons of phenotype between children with regressive ASD and their siblings. oEmphasis on environmental factors that influence prenatal and early postnatal development is particularly of high priority. Epidemiological studies should pay special attention to include racially and ethnically diverse populations. IACC Recommended Budget: $12,000,000 over 5 years.

Project Link

Project Link

Structural and functional neural correlates of early postnatal deprivation (External web link)

Institution

Institution

Wayne State University

State/Country

State/Country

Michigan

Project Number

Project Number

5K08MH079176-04

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Structural and functional neural correlates of early postnatal deprivation | 148768 | 2009 | 5K08MH079176-03
Structural and functional neural correlates of early postnatal deprivation | 145003 | 2008 | K08MH079176-02

 
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