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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Elevated urinary P-cresol: Intestinal causes and behavioral consequences

Principal Investigator

Principal Investigator

Persico, Antonio

Description

Description

This study examines clostridia and para-cresol in individuals with ASD. Initial research studies demonstrate a significant increase in urinary p-cresol concentrations among ASD patients compared with matched controls. Urinary p-cresol cannot derive from human metabolism; it can either stem from the presence of clostridium difficile in the gut or from toxic contamination with p-cresol-containing hydrocarbon mixtures. Excess urinary p-cresol may originate from abnormal gut flora or excessive gut permeability in children with ASD. This study intends to define the degree of overlap between elevated urinary p-cresol, clostridial gut infection, and enhanced intestinal permeability. The correlation between urinary p-cresol and a clinical history of regression will also be examined in study subjects. Finally, preliminary experiments will be conducted on approximately 12 young and adult rodents by injecting p-cresol to assess whether and to what extent p-cresol can influence the development and/or function of the central nervous system.

Funder

Funder

Autism Research Institute

Fiscal Year Funding

Fiscal Year Funding

25000

Current Award Period

Current Award Period

2010

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SI. Support at least two studies that examine potential differences in the microbiome of individuals with ASD versus comparison groups by 2012. IACC Recommended Budget: $1,000,000 over 2 years.

Project Link

Project Link

Elevated urinary P-cresol: Intestinal causes and behavioral consequences (External web link)

Institution

Institution

Universita Campus Bio-Medico di Roma

State/Country

State/Country

Italy

Project Number

Project Number

2010-8

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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