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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Analysis of the small intestinal microbiome of children with autism

Principal Investigator

Principal Investigator

Kushak, Rafail

Description

Description

Many children with autism spectrum disorders (ASD) experience gastrointestinal symptoms such as abdominal pain, constipation, diarrhea, and bloating that exacerbate their behavioral problems. These symptoms may be related to alterations in microbial flora in the intestine. Evidence on the effect of gut flora on children with autism is very limited; however, even in healthy humans intestinal microflora is largely unexplored. Modern culturing-independent techniques allow studying complex microbial ecosystems (microbiomes) containing at least 100 times as many genes as human genome. The most informative is technique based on gene analysis of specific RNA found in all microorganisms. This novel approach was successfully used for the analysis of colon mucosa and stool samples in healthy humans and patients with inflammatory bowel disease. However, microbiome of the upper part of gastrointestinal tract in humans has been understudied in comparison to that of the colon. The objective of our study is to evaluate the entire microbial population in the upper gastrointestinal tract of children with autism to determine if there is an overgrowth of specific populations of bacteria. These data will be correlated with questionnaires on gastrointestinal symptoms and autistic behavior. The genomic data from this study might be of interest in terms of understanding the role of upper gut microorganisms in the etiology of autism and use of therapeutic strategies to alter intestinal flora.

Funder

Funder

Department of Defense

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2010-2012

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SI. Support at least two studies that examine potential differences in the microbiome of individuals with ASD versus comparison groups by 2012. IACC Recommended Budget: $1,000,000 over 2 years.

Project Link

Project Link

Analysis of the small intestinal microbiome of children with autism (External web link)

Institution

Institution

Massachusetts General Hospital

State/Country

State/Country

Massachusetts

Project Number

Project Number

AR093450

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Analysis of the small intestinal microbiome of children with autism | 132750 | 2009 | AR093450
Analysis of the small intestinal microbiome of children with autism | 0 | 2011 | AR093450
Analysis of the small intestinal microbiome of children with autism | 0 | 2012 | AR093450

 
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