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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Epigenetic marks as peripheral biomarkers of autism

Principal Investigator

Principal Investigator

Warren, Stephen

Description

Description

Autism is a common disorder whose causes are poorly understood. Both genetic and environmental influences are thought to act together causing autism. Epigenetics is an area that bridges genetic and environmental factors and commonly is studied by examining dynamic methylation changes to the DNA. Prior research screened a total of 78 autistic boys and their fathers by this method in 807 genes and found 116 methylation changes that together can correctly identify nearly 80% of the affected boys from their fathers. In this study, these data will be confirmed in a much larger set of genes in 1,200 autistic boys and their families, including unaffected brothers. These data not only could provide new insight into the causes of autism but could also result in a screening test for autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

949623

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Project Link

Project Link

Epigenetic marks as peripheral biomarkers of autism (External web link)

Institution

Institution

Emory University

State/Country

State/Country

Georgia

Project Number

Project Number

5R01MH089606-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Epigenetic marks as peripheral biomarkers of autism | 2198844 | 2009 | 1R01MH089606-01

 
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