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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Project 3: Neurodevelopmental toxicology of autism

Principal Investigator

Principal Investigator

Pessah, Isaac

Description

Description

The goal of this project (one of three interrelated projects at the University of California-Davis Center for Children's Environmental Health (CCEH) is to determine if exposure to environmental toxicants early in development contributes to the etiology of neurodevelopmental disorders such as autism. A related goal is to determine whether susceptibility to autoimmune disease increases the neurotoxicity of environmental contaminants and increases the risk for developing disorders such as autism. The study will expose mouse strains with low or high susceptibility to autoimmunity perinatally to either methylmercury, polychlorinated biphenyl 95, or polybrominated diphenyl ether 47. The effects of toxicant exposure between these mouse strains on brain development, complex social behaviors, and immune system function will then be compared. Understanding how exposure to environmental toxicants may contribute to the etiology of neurodevelopmental disorders is important so that the exposure risks can be identified and minimized.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

173583

Current Award Period

Current Award Period

2006-2013

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SK. Support two studies and a workshop that facilitate the development of vertebrate and invertebrate model systems for the exploration of environmental risks and their interaction with gender and genetic susceptibilities for ASD by 2012. IACC Recommended Budget: $1,535,000 over 3 years.

Project Link

Project Link

Project 3: Neurodevelopmental toxicology of autism (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

5P01ES011269-10

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Project 3: Neurodevelopmental toxicology of autism | 136181 | 2009 | 5P01ES011269-09
Project 3: Neurodevelopmental toxicology of autism | 136640 | 2008 | P01ES011269-08

 
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