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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Sex chromosomes, epigenetics, and neurobehavioral disease

Principal Investigator

Principal Investigator

Rissman, Emilie

Description

Description

Given the large sex differences in the prevalence of several neurobehavioral diseases (for example, autism is found 4 times more often in boys than in girls), this study focuses on epigenetic modification of mechanisms that underlie sex differences in behavior. This study will evaluate whether the endocrine disrupting compound, bisphenol A (BPA), can modify sex differences in behavior and, if so, whether it acts on X-chromosome genes that may be linked to diseases. Genetically engineered mice, molecular, genetic ,and behavioral methods will be used to reveal epigenetic interactions between sex chromosome genes and BPA. Specifically, the effects of sex chromosomes and BPA on juvenile social behavior in mice will be assessed, and gene expression arrays of candidate genes affected by BPA exposure during neural development will be conducted. The effects of BPA on DNA methylation and histone modification will also be examined. The goal of this research is to find genes and processes that can help diagnose, treat, and prevent mental illnesses.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

382757

Current Award Period

Current Award Period

2009-2012

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SK. Support two studies and a workshop that facilitate the development of vertebrate and invertebrate model systems for the exploration of environmental risks and their interaction with gender and genetic susceptibilities for ASD by 2012. IACC Recommended Budget: $1,535,000 over 3 years.

Project Link

Project Link

Sex chromosomes, epigenetics, and neurobehavioral disease (External web link)

Institution

Institution

University of Virginia

State/Country

State/Country

Virginia

Project Number

Project Number

5R01MH086711-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Sex chromosomes, epigenetics, and neurobehavioral disease | 374036 | 2009 | 1R01MH086711-01

 
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