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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The effects of oxytocin on complex social cognition in autism spectrum disorders

Principal Investigator

Principal Investigator

Bartz, Jennifer

Description

Description

Social impairment is a central, unifying feature of autism and autism spectrum disorders (ASD), and perhaps also the most debilitating, but there has been little headway in the development of pharmacological treatments for the social domain. The purpose of this research is to determine whether oxytocin-a peptide hormone that plays a role in affiliative behavior in animals facilitates complex social cognition in adults with ASD and to elucidate the neurobiological mechanism involved in this process to clarify the viability of this potentially ground breaking treatment. Specifically, 35 adults with ASD will randomly receive a single dose of synthetic oxytocin, administered via nasal spray, or a matching placebo on two separate occasions. Researchers will then assess performance on a novel, complex social cognition task as well as brain activation using functional magnetic resonance imaging (fMRI). If positive, this research will point to a novel, potentially groundbreaking therapeutic candidate to target social dysfunction in ASD. Moreover, the focus on adults with ASD will be an important contribution to the field of autism because to date there is a paucity of effective interventions for adults with ASD.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

285221

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4LA. Complete at least three randomized controlled trials on medications targeting core symptoms in people with ASD of all ages by 2014. IACC Recommended Budget: $22,200,000 over 5 years.

Project Link

Project Link

The effects of oxytocin on complex social cognition in autism spectrum disorders (External web link)

Institution

Institution

Mount Sinai School of Medicine

State/Country

State/Country

New York

Project Number

Project Number

5R21HD065276-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

The effects of oxytocin on complex social cognition in autism spectrum disorders | 279520 | 2009 | 1R21HD065276-01

 
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