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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Center: Understanding repetitive behavior in autism

Principal Investigator

Principal Investigator

McCracken, James

Description

Description

This grant provides support for an NIH Autism Center of Excellence (ACE). Repetitive behaviors form a core feature of autism spectrum disorders (ASD), but the understanding of the neural basis of stereotypy and repetitive behaviors in ASD and their treatment is limited. Recently, risperidone, an antipsychotic, was observed to robustly reduce stereotypic behaviors in a sample of children and adolescents with autism. The proposed study attempts to increase understanding of repetitive behaviors in ASD and its treatment by examining the changes in key neural circuits associated with risperidone treatment using functional magnetic resonance imaging (fMRI). The proposed clinical trial and study design provide a unique opportunity to study the biology of treatment response on the target of repetitive behaviors which could cast a broader light on the nature of brain dysfunction across these similar parallel distributed brain systems and their interactions.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

326665

Current Award Period

Current Award Period

2007-2012

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4LA. Complete at least three randomized controlled trials on medications targeting core symptoms in people with ASD of all ages by 2014. IACC Recommended Budget: $22,200,000 over 5 years.

Project Link

Project Link

ACE Center: Understanding repetitive behavior in autism (External web link)

Institution

Institution

University of California, Los Angeles

State/Country

State/Country

California

Project Number

Project Number

5P50HD055784-04

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

ACE Center: Understanding repetitive behavior in autism | 330198 | 2009 | 5P50HD055784-03
ACE Center: Understanding repetitive behavior in autism (supplement) | 55094 | 2009 | 3P50HD055784-03S1

 
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