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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Targeted pharmacologic interventions for autism

Principal Investigator

Principal Investigator

McDougle, Christopher

Description

Description

This project will examine the efficacy and tolerability of atomoxetine for treatment of hyperactivity associated with autism in children and adolescents. An 8-week randomized clinical trial will be conducted, and patients that respond well to short-term treatment with atomoxetine will be followed for an additional 10 months. Genetic polymorphisms of the cytochrome P450 2D6 gene will also be analyzed to determine their relationship to response and tolerability to atomoxetine. This research addresses the need to find safer and more effective medical treatments for autism and is also unique in its plan to identify genetic predictors of response to drug treatment in autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

370481

Current Award Period

Current Award Period

2007-2012

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4LC. Conduct at least one study to evaluate the safety and effectiveness of medications commonly used in the treatment of co-occurring conditions or specific behavioral issues in people with ASD by 2015. IACC Recommended Budget: $10,000,000 over 5 years.

Project Link

Project Link

Targeted pharmacologic interventions for autism (External web link)

Institution

Institution

Indiana University-Purdue University Indianapolis

State/Country

State/Country

Indiana

Project Number

Project Number

5R01MH077600-04

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Targeted pharmacologic interventions for autism | 355516 | 2009 | 5R01MH077600-03
Targeted pharmacologic interventions for autism | 341475 | 2008 | R01MH077600-02

 
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