Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Metabolic biomarkers of autism: Predictive potential and genetic susceptibility

Principal Investigator

Principal Investigator

James, Sandra

Description

Description

Based on these researchers' recent discovery that children with autism exhibit abnormal methionine and glutathione metabolism, this project aims to identify if metabolic imbalance results in increased oxidative stress and impaired methylation capacity that may contribute, in part, to the development and clinical manifestations of autism. The researchers will also study if an abnormal metabolic profile is associated with increased frequency of genetic polymorphisms that functionally affect methionine and glutathione metabolism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

369495

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1.3 Identify a panel of biomarkers that separately, or in combination with behavioral measures, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

Arkansas Children's Hospital Research Institute

State/Country

State/Country

Arkansas

Project Number

Project Number

R01HD051873-03

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Metabolic biomarkers of autism: Predictive potential and genetic susceptibility | 351076 | 2010 | 5R01HD051873-05
Metabolic biomarkers of autism: Predictive potential and genetic susceptibility | 380150 | 2009 | 5R01HD051873-04

 
Back to Top