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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Molecular and genetic epidemiology of autism

Principal Investigator

Principal Investigator

Pericak-Vance, Margaret

Description

Description

This research will expand and build on previous results embracing the paradigm that the wedding of new genomic technology with novel statistical methodology will bring about success. Specifically, researchers will 1) Broaden the ascertainment scheme to include the full range of the autism spectrum disorder phenotype, 2) Identify the chromosome 19 autism gene, 3) Investigate a newly defined linkage to chromosome 12 in large extended multigenerational autism families, 4) Extend studies of the GABA receptor subunits genes, 5) Identify clinically homogeneous subsets of patients and families and use the refined dataset to fine map ASD chromosomal regions and in candidate gene analyses, 6) Test for evidence of new gene/gene interactions to fully explain the spectrum of autism risk.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

1166487

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3.2 Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. IACC Recommended Budget: $43,700,000 over 4 years.

Project Link

Project Link

No link available.

Institution

Institution

University of Miami Miller School of Medicine

State/Country

State/Country

Florida

Project Number

Project Number

R01MH080647-12

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Molecular and genetic epidemiology of autism | 1211372 | 2009 | 5R01MH080647-13
Molecular and genetic epidemiology of autism | 1186466 | 2010 | 5R01MH080647-14

 
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