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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A mouse knock-in model for Engrailed 2 autism susceptibility

Principal Investigator

Principal Investigator

Millonig, James

Description

Description

Although there is strong evidence for a genetic contribution to ASD, the isolation of specific causative genetic defects has been difficult. The researchers' previous work has focused on the homeobox transcription factor ENGRAILED 2 (EN2). They have demonstrated consistent association for two intronic EN2 SNPs, rs1861972 and rs1861973, in three separate datasets. These findings determined that EN2 is a likely ASD susceptibility gene.The goal of this study is to generate a mouse model for the EN2 risk allele by using recombinase- mediated genomic replacement (RMGR).

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

152764

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4.5 Standardize and validate at least 20 model systems (e.g. cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School

State/Country

State/Country

New Jersey

Project Number

Project Number

R21MH083509-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

A mouse knock-in model for ENGRAILED 2 autism susceptibility | 227135 | 2010 | 4R33MH083509-03
A mouse knock-in model for ENGRAILED 2 autism susceptibility | 152667 | 2009 | 5R21MH083509-02

 
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