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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Ube3a requirements for structural plasticity of synapses

Principal Investigator

Principal Investigator

McCoy, Portia

Description

Description

Some autism spectrum disorders are caused by the improper expression of a gene termed UBE3A. Having duplications of the UBE3Agene is strongly associated with autism, while deletions of the UBE3A gene cause the severe intellectual disability “Angelman Syndrome”. Both disorders are characterized by cognitive, sensory, and behavioral deficits thought to arise because connections between brain neurons (synapses) form improperly during critical periods of development. However, little is known about how changes in UBE3A expression alter the wiring of neurons in the brain. This study aims to determine the role of UBE3A in the structural plasticity of synapses during critical periods of brain development. By filling this gap in knowledge, this study will not only reveal the synaptic structural dysfunction leading to improper circuit formation in UBE3A-related forms of autism, but may also serve as a model to help with therapeutic testing.

Funder

Funder

Autism Science Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2010-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

Ube3a requirements for structural plasticity of synapses (External web link)

Institution

Institution

University of North Carolina at Chapel Hill

State/Country

State/Country

North Carolina

Project Number

Project Number

N/A

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Ube3a requirements for structural plasticity of synapses | 40000 | 2010 | n/a

 
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