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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Identifying impairments in synaptic connectivity in mouse models of ASD

Principal Investigator

Principal Investigator

Speed, Haley

Description

Description

Impaired communication between neurons, or synaptic transmission, is thought to underlie autism-associated behaviors. The goal of this research project is to identify specific deficits in synaptic transmission as novel targets for future therapy. Shank3 is a postsynaptic scaffolding protein required for normal synapse maturation and function, and mutations and copy number variations in the Shank3 gene have been directly implicated in heritable autism with mental retardation in humans. Our laboratory will use genetic mouse models of autism containing regional deletions of the Shank3 gene to 1) Understand how the structure and function of hippocampal synapses are impaired by region-specific mutations in the Shank3 gene, and 2) Determine if each mutation contributes to autism-associated deficits in learning and memory. This thorough, interdisciplinary strategy will identify subcellular mechanisms that will immediately translate into pre-clinical studies for treatment of autism-associated behavioral deficits.

Funder

Funder

Autism Science Foundation

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2010-2011

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Identifying impairments in synaptic connectivity in mouse models of ASD (External web link)

Institution

Institution

University of Texas Southwestern Medical Center

State/Country

State/Country

Texas

Project Number

Project Number

N/A

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Identifying impairments in synaptic connectivity in mouse models of ASD | 40000 | 2010 | n/a

 
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