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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Neurogenic growth factors in autism

Principal Investigator

Principal Investigator

Vaccarino, Flora

Description

Description

In addition to their prominent role in certain types of cancer, genes in the fibroblast growth factor (FGF) pathway have been shown in animal models to be important for brain development. Animals with mutations in FGF genes, for instance, exhibit anatomical characteristics reminiscent of those observed in autism. Dr. Vaccarino plans to investigate these genes for variants associated with autism. Using samples she collected as well as those from Autism Genetic Resource Exchange (AGRE), she also plans to correlate changes in these genes associated with autism with changes in brain size and structures.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2008-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

Neurogenic growth factors in autism (External web link)

Institution

Institution

Yale University

State/Country

State/Country

Connecticut

Project Number

Project Number

1883

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Neurogenic growth factors in autism | 0 | 2009 | 1883
Neurogenic growth factors in autism | 112494 | 2010 | 1883
Neurogenic growth factors in autism | 150000 | 2008 | 1883

 
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