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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Characterization of the sleep phenotype in adolescents and adults with autism spectrum disorder

Principal Investigator

Principal Investigator

Goldman, Suzanne

Description

Description

Adolescence, a time of transition fraught with physical, hormonal, emotional, and social changes is daunting for typically developing children. These challenges are magnified in children with autism. With 1 in 110 children being diagnosed with autism it is imperative to become proactive and begin to address the challenges these children may face in future years. Sleep problems are major health concerns in autistic children and it is expected that problematic sleep will extend into the adolescent and young adult years. Currently, there is little information available to help parents through this transition. This study aims to model the sleep behaviors in adolescents and young adults with autism and determine how sleep affects daytime behavior. The goals of this study are to characterize the sleep phenotype and its association with daytime sleepiness and problematic behaviors in adolescents/young adults with autism; and to define predictors and outcomes for future targeted interventions. It is hypothesized that delayed sleep phase, measured with actigraphy and serial melatonin, will be more predominant than insomnia in these individuals and greater than in age-gender matched typically developing individuals. The investigators use a multidimensional approach including sleep questionnaires and wrist actigraphy to characterize sleep behavior. Saliva will be collected to measure melatonin to model circadian patterns. Daytime behavior will be measured with standardized questionnaires. Understanding the sleep patterns of these individuals will allow to formulation of future treatments that target behavioral aspects of disturbed sleep, or determine specific pharmacological agents (e.g., melatonin) for future intervention studies. The long-range goal is to improve sleep and daytime behaviors in adolescents and young adults with autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2011-2014

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Characterization of the sleep phenotype in adolescents and adults with autism spectrum disorder (External web link)

Institution

Institution

Vanderbilt University

State/Country

State/Country

Tennessee

Project Number

Project Number

7722

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Characterization of the sleep phenotype in adolescents and adults with autism spectrum disorder | 150000 | 2012 | 7722
Characterization of the sleep phenotype in adolescents and adults with autism spectrum disorder | 150000 | 2014 | 7722
Characterization of the sleep phenotype in adolescents and adults with autism spectrum disorder | 0 | 2015 | 7722
Characterization of the sleep phenotype in adolescents and adults with autism spectrum disorder | 150000 | 2013 | 7722

 
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