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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The role of the neurexin 1 gene in susceptibility to autism

Principal Investigator

Principal Investigator

Gusella, James

Description

Description

Neurexin 1 (NRXN1) was recently implicated as an autism susceptibility gene. The association is intriguing because it interacts with neuroligin-3 and SHANK3 (two other genes previously found to generate risk for autism and mental retardation) at synaptic junctions to help regulate synapse formation. Dr. Gusella and his colleagues plan to examine NRXN1 in samples from AGRE and samples collected by collaborators for mutations or variations that could disrupt its function and determine if it plays a role in a larger proportion of autism cases. In addition, since the samples will be clinically well characterized, there is also an opportunity to establish a more robust correlation between genetic variation and clinical presentation.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2007-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Project Link

Project Link

The role of the neurexin 1 gene in susceptibility to autism (External web link)

Institution

Institution

Massachusetts General Hospital/Harvard Medical School

State/Country

State/Country

Massachusetts

Project Number

Project Number

2042

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The role of the neurexin 1 gene in susceptibility to autism | 0 | 2009 | 2042
The role of the neurexin 1 gene in susceptibility to autism | 127500 | 2010 | 2042
The role of the neurexin 1 gene in susceptibility to autism | 150000 | 2008 | 2042

 
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