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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity

Principal Investigator

Principal Investigator

Comoletti, Davide

Description

Description

Among the genetic mutations associated with a susceptibility to autism are those found in two families of genes, the neurexins and the neuroligins. Neurexins are present in the presynaptic cell (the cell sending information), and neuroligins are present on the postsynaptic cell (the cell receiving information). Because neurexins and neuroligins recognize and bind each other very specifically, they are thought to be involved in the formation and maintenance of synapses and to be involved in the specification of particular synaptic connections between particular cells of the brain. In this study, Dr. Comoletti and colleagues will study the molecular basis of the interaction between neurexins and neuroligins: by mutating various regions of each gene, they will determine which parts of the encoded proteins are important for these physical interactions to occur.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2008-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity (External web link)

Institution

Institution

University of California, San Diego

State/Country

State/Country

California

Project Number

Project Number

2617

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity | 60000 | 2009 | 2617
Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity | 60000 | 2008 | 2617
Neuroligins and neurexins as autism candidate genes: Study of their association in synaptic connectivity | 60000 | 2010 | 2617

 
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