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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Autism spectrum disorder in Down syndrome: A model of repetitive and stereotypic behavior for idiopathic ASDĀ 

Principal Investigator

Principal Investigator

Kaufmann, Walter

Description

Description

Down syndrome is the most common genetic disorder associated with neurobehavioral problems, and many children with Down syndrome have clinically significant behavioral problems, including autism spectrum disorders (ASD). Preliminary research from Dr. Kaufmann's lab has shown that children with both Down syndrome and ASD have a unique profile of autistic core symptoms, including severe stereotypies (repetitive movements) which are distinct from more common movement disorders associated with Down syndrome. The present study will test and further confirm the hypothesis that the diagnosis of Down syndrome plus ASD is associated with both a unique behavioral profile and distinctive genetic characteristics. 70 boys with Down syndrome, with and without ASD, will be recruited for this study. Subjects will be evaluated for behavioral problems, including stereotypies and developmental regression, using methods of analysis which have not yet been applied to studying behavior in Down syndrome. This research may lead to improved diagnoses and treatment of Down syndrome plus ASD, and provide insight into various behavioral aspects of ASDs.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.

Project Link

Project Link

Autism spectrum disorder in Down syndrome: A model of repetitive and stereotypic behavior for idiopathic ASDĀ  (External web link)

Institution

Institution

Kennedy Krieger Institute

State/Country

State/Country

Maryland

Project Number

Project Number

2622

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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