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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Potential role of non-coding RNAs in autism 

Principal Investigator

Principal Investigator

Talebizadeh, Zohreh

Description

Description

Genetic predisposition to autism may involve both differences in the coding regions of DNA (genomic regions encoding RNAs which are eventually translated into proteins) and changes in the regulation of gene expression, though the coding regions of DNA are unaffected. A recently discovered mechanism for the regulation of gene expression is non-coding RNAs (RNAs which do not get translated into proteins). Non-coding RNAs may regulate the translation of other RNAs to proteins. Changes in expression of these non-coding RNAs could potentially be involved in the development of autism. This study aims to characterize the non-coding RNAs present in autistic individuals compared to normal individuals. Researchers will use microarray technology capable of measuring the levels of thousands of individual RNAs to identify which non-coding RNAs are expressed at different levels in blood cells from autistic versus non-autistic subjects. Examining non-coding RNAs is a novel approach to discovering the biological mechanisms underlying autism and may identify novel drug targets for the treatment and prevention of autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Project Link

Project Link

Potential role of non-coding RNAs in autism  (External web link)

Institution

Institution

Children's Mercy Hospitals And Clinics 

State/Country

State/Country

Missouri

Project Number

Project Number

2578

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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