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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

fMRI evidence of genetic influence on rigidity in ASD

Principal Investigator

Principal Investigator

Lee, Jillian

Description

Description

A hallmark symptom of autism is rigidity, or difficulty in adapting to changing environments. This adaptive ability is also known as cognitive flexibility. The present study will examine the association between cognitive flexibility, pathways of neural activity, and a particular autism-linked gene, 5-HTTLPR, which is involved in signaling by the neurotransmitter serotonin. Using functional magnetic resonance imaging (fMRI), the predoctoral fellow will test the hypothesis that variation in the 5-HTTLPR gene is related to rigidity symptoms. She will use fMRI to look at the patterns of neural activity while ASD individuals perform a task measuring cognitive flexibility. The subjects will include people with multiple different alleles of the 5-HTTPLPR gene. This will determine whether different 5-HTTLPR genotypes are associated with abnormal brain activation patterns during cognitive flexibility tasks or with the severity of rigidity symptoms. This research may identify genetically influenced neural and cognitive abnormalities affecting cognitive flexibility that could potentially be targeted by therapies to alleviate symptoms of rigidity.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2008-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

fMRI evidence of genetic influence on rigidity in ASD (External web link)

Institution

Institution

University of Michigan

State/Country

State/Country

Michigan

Project Number

Project Number

4773

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

FMRI evidence of genetic influence on rigidity in ASD | 28000 | 2008 | 4773
fMRI evidence of genetic influence on rigidity in ASD | 28000 | 2009 | 4773
fMRI evidence of genetic influence on rigidity in ASD | 0 | 2010 | 4773

 
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