Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure

Principal Investigator

Principal Investigator

Keller, Flavio

Description

Description

This project will investigate the role of three separate factors in an animal model of autism spectrum disorder: a) genetic susceptibility, b) hormonal environment, and c) possible environmental triggers. A mouse model with a mutation of the reelin gene, implicated in autism spectrum disorders, will be studied after exposure to methyl and ethyl mercury. Both behaviors and neuropathological endpoints will be explored. Finally, the role of endogenous sex hormones will be examined by eliminating the testosterone “surge” around the time of puberty. The individual effects of each will be examined as well as the interaction of the three components (genetic liability, environmental exposure, hormonal influences) to determine gene x environment interactions. This study will use a unique design to study multiple factors in the etiology of autism spectrum disorder in a mouse model, isolating and combining factors which previously have been implicated in the pathophysiology and behavioral phenotype.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2008-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SK. Support two studies and a workshop that facilitate the development of vertebrate and invertebrate model systems for the exploration of environmental risks and their interaction with gender and genetic susceptibilities for ASD by 2012. IACC Recommended Budget: $1,535,000 over 3 years.

Project Link

Project Link

Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure (External web link)

Institution

Institution

Universita Campus Bio-Medico di Roma

State/Country

State/Country

Italy

Project Number

Project Number

4919

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure | 92582 | 2010 | 4919
Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure | 92582 | 2009 | 4919
Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure | 110000 | 2008 | 4919
Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure | 0 | 2012 | 4919

 
Back to Top