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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Assisted reproductive treatments and risk of autism

Principal Investigator

Principal Investigator

Reichenberg, Avi

Description

Description

In the past decade, the use of assisted reproductive treatments such as in vitro fertilization and intracytoplasmatic sperm injection has consistently increased, with approximately 1% of infants born in 2004 being conceived through such treatments. As well, there is accumulating evidence suggesting that there may be a relationship between the use of assisted reproductive treatments and autism spectrum disorders (ASD) in children born as the result of such treatments. In the present study, researchers will use population-based health records collected in Sweden for all infants born between 1982 and 2001, including those born after assisted reproduction treatments. Dr. Reichenberg and colleagues will analyze the data to determine whether diagnoses of ASD link to the use of assisted reproductive treatments as well as to other potentially relevant factors such as parental age and perinatal indices such as birth weight.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SH. Support at least three studies of special populations or use existing databases to inform our understanding of environmental risk factors for ASD in pregnancy and the early postnatal period by 2012. Such studies could include: o Comparisons of populations differing in geography, gender, ethnic background, exposure history (e.g., prematurity, maternal infection, nutritional deficiencies, toxins), and migration patterns; and o Comparisons of phenotype (e.g., cytokine profiles), in children with and without a history of autistic regression, adverse events following immunization (such as fever and seizures), and mitochondrial impairment. These studies may also include comparisons of phenotype between children with regressive ASD and their siblings. Emphasis on environmental factors that influence prenatal and early postnatal development is particularly of high priority. Epidemiological studies should pay special attention to include racially and ethnically diverse populations. IACC Recommended Budget: $12,000,000 over 5 years.

Project Link

Project Link

Assisted reproductive treatments and risk of autism (External web link)

Institution

Institution

Institute of Psychiatry, King's College London

State/Country

State/Country

United Kingdom

Project Number

Project Number

3681

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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