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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

How does IL-6 mediate the development of autism-related behaviors?

Principal Investigator

Principal Investigator

Hsiao, Elaine

Description

Description

Maternal infection is an environmental factor that can increase the incidence of autism in the offspring. In an animal model of this risk factor, respiratory infection of pregnant mice yields offspring that develop behavioral abnormalities and neuropathology consistent with those observed in autistic patients. These changes can be mimicked by maternal injection of the dsRNA, poly(I:C), which evokes an anti-viral inflammatory response. Recent studies have shown that the cytokine interleukin-6 (IL-6) is necessary and sufficient for mediating the development of behavioral and transcriptional changes in this maternal immune activation (MIA) model. While IL-6 is critical for mediating the effects of MIA, the mechanism by which IL-6 acts to alter neural development is unknown. Preliminary results indicate that IL-6 activates cells in the placenta and fetal brain, causing the induction of IL-6 response genes and IL-6 mRNA as well. This project will identify the cells that respond to IL-6 and localize the source(s) of IL-6 production. The long-term goals are to elucidate the molecular mechanisms by which IL-6 alters fetal brain development and to discover how these defects influence postnatal behavioral dysfunction.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

How does IL-6 mediate the development of autism-related behaviors? (External web link)

Institution

Institution

California Institute of Technology

State/Country

State/Country

California

Project Number

Project Number

6330

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

How does IL-6 mediate the development of autism-related behaviors? | 28000 | 2009 | 3628
How does IL-6 mediate the development of autism-related behaviors? | 28000 | 2010 | 6330

 
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