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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A role for immune molecules in cortical connectivity: Potential implications for autism

Principal Investigator

Principal Investigator

Elmer, Bradford

Description

Description

The study will use molecular biology and biochemical techniques to alter the function of MHCI and MEF2 in brain cells to probe the molecular pathway underlying their function. By defining the relationship between these two proteins with respect to synapse formation, this study will increase understanding of how the immune system could alter connections in the developing brain to give rise to neurodevelopmental disorders. Results from the study could identify novel drug targets for treating diseases that are influenced by immune dysregulation, such as autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2010-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

A role for immune molecules in cortical connectivity: Potential implications for autism (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

6339

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

A role for immune molecules in cortical connectivity: Potential implications for autism | 28000 | 2009 | 4934
A role for immune molecules in cortical connectivity: Potential implications for autism | 28000 | 2010 | 6339

 
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