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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Folate rechallenge: A pilot study

Principal Investigator

Principal Investigator

Beaudet, Arthur

Description

Description

Autism spectrum disorder (ASD) may be associated with abnormalities in folate metabolism, which is a process that affects genetic expression by facilitating the formation of methyl donors for DNA methylation. Limited data show that some children with ASD show behavioral improvements with folic acid (FA) therapy, while others show a worsening effect. If behavioral worsening is linked with abnormalities in folate metabolism, then nutritional modifications could normalize these processes and result in clinical improvements. To address this premise, a randomized, placebo-controlled crossover pilot study with two phases is proposed. The first phase will focus on the behavioral and biochemical responses of children with ASD to high-dose folic acid supplementation. Because FA is an inactive folate that requires biochemical conversion to become active, and select genotypes impede this conversion, the hypothesis is that FA will yield behavioral improvements in some children but exacerbate problem behaviors in others. During the second phase, children who had a worsened behavioral response to FA during phase 1 will participate in an open-label trial of high-dose Metafolin (an active folate metabolite) supplementation. Results from this project may provide support for continued study of the potential relationship between folate metabolism and problem behaviors among children with ASD, potentially justifying the need to examine effects of folate supplementation among a larger sample of affected children.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

6332

Current Award Period

Current Award Period

2010-2011

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SC. Test safety and efficacy of at least five widely used interventions (e.g., nutrition, medications, assisted technologies, sensory integration, medical procedures) that have not been rigorously studied for use in ASD by 2012. IACC Recommended Budget: $27,800,000 over 5 years.

Project Link

Project Link

Folate rechallenge: A pilot study (External web link)

Institution

Institution

Baylor College of Medicine

State/Country

State/Country

Texas

Project Number

Project Number

5M01RR000188-47

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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