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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Medical etiologies of neurodevelopmental disorders: Cerebral folate deficiency

Principal Investigator

Principal Investigator

Frye, Richard

Description

Description

This grant supported research into the prevalence of cerebral folate deficiency and folate receptor autoantibodies (FRAs) in children with autism spectrum disorders (ASD) and the effect of folinic acid treatment in children with ASD and FRAs. The study measured serum FRAs concentrations in 93 children with ASD. A high prevalence rate (75.3 percent) of FRAs was found in the children participating in the study. Children with FRAs were treated with oral leucovorin calcium (folinic acid), and treatment response was measured and compared with a wait-list control group. Compared with controls, significantly higher improvement ratings were observed in treated children over a mean period of 4 months, in the areas of verbal communication, receptive and expressive language, attention, and stereotypical behavior.

Funder

Funder

Autism Research Institute

Fiscal Year Funding

Fiscal Year Funding

6900

Current Award Period

Current Award Period

2011.0

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SC. Test safety and efficacy of at least five widely used interventions (e.g., nutrition, medications, assisted technologies, sensory integration, medical procedures) that have not been rigorously studied for use in ASD by 2012. IACC Recommended Budget: $27,800,000 over 5 years.

Project Link

Project Link

Medical etiologies of neurodevelopmental disorders: Cerebral folate deficiency (External web link)

Institution

Institution

Children's Learning Institute at the University of Texas Health Science Center at Houston

State/Country

State/Country

Texas

Project Number

Project Number

2011-7

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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