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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A multi-site double-blind placebo-controlled trial of memantine vs. placebo in children with autism

Principal Investigator

Principal Investigator

Anagnostou, Evdokia

Description

Description

Abnormalities in the modulation of the glutamate system have been reported by multiple investigators studying animal models, post-mortem brains, and single gene disorders that have overlapping phenotypes with autism. Abnormalities in glutamatergic function have been reported in disorders affecting a variety of behavioral and neurological domains, from mood stability, to cognitive flexibility, memory, and motor function. Numerous studies have reported a variety of memory and motor deficits in children with autism. Whereas the neurobiology of such deficits is an area of active research, there is a paucity of intervention research for such deficits in autism. This study will attempt to study the effect of an NMDA inhibitor, memantine, on memory, and motor praxis/expressive language skills in children with autism. Children ages 6-12 years who are verbal and meet criteria for autism spectrum disorder will be recruited across 3 sites. After consent, the children will be assessed for memory function, expressive language output and motor skills/praxis. They will then be randomized 1:1 to memantine vs. placebo for 6 months. The effects of this medication on the above mentioned symptoms domains as well as its safety in this population will be studied over the 6 month period.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

97238

Current Award Period

Current Award Period

2011-2013

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4LA. Complete at least three randomized controlled trials on medications targeting core symptoms in people with ASD of all ages by 2014. IACC Recommended Budget: $22,200,000 over 5 years.

Project Link

Project Link

A multi-site double-blind placebo-controlled trial of memantine vs. placebo in children with autism (External web link)

Institution

Institution

Holland Bloorview Kids Rehabilitation Hospital

State/Country

State/Country

Canada

Project Number

Project Number

7763

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

A multi-site double-blind placebo-controlled trial of memantine vs. placebo in children with autism | 0 | 2012 | 7763
A multi-site double-blind placebo-controlled trial of memantine vs. placebo in children with autism | 0 | 2013 | 7763

 
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