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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Evidence-based cognitive rehabilitation to improve functional outcomes for young adults with autism spectrum disorders

Principal Investigator

Principal Investigator

Minshew, Nancy

Description

Description

This project proposes to bring an evidence-based, innovative cognitive rehabilitation approach (Cognitive Enhancement Therapy - CET) to young verbal adults with autism spectrum disorders (ASD) who often experience substantial lifelong disability. At the core of these disorders are problems in thinking and social-emotional functioning that lead to substantial disability, particularly as individuals transition to adulthood. Unfortunately, few interventions are available for adults with ASD, and even fewer focus on the remediation of cognitive and social-emotional deficits that impede the development of complex adaptive behaviors which are essential for achievement in adult life. To address this major gap in the treatment of ASD, the study will adapt and test the efficacy of CET with young transitional-age high-functioning adults with ASD. CET is a social-cognitive and neurocognitive rehabilitation program originally developed for schizophrenia that has demonstrated significant improvements in many of the cognitive and functional domains impaired in ASD. This project will first adapt the CET treatment to reflect the uniqueness of autism, and then proceed to conduct a small-scale randomized trial with 48 young adults with ASD to obtain initial efficacy data on cognitive and functional outcomes to support the feasibility of a larger and more definitive trial. The proposed project will be the first rigorous clinical trial of a proven cognitive rehabilitation approach with verbal adults with ASD. If successful, this project will represent a major step forward in the treatment of verbal adults with ASD, and have implications for both younger individuals with autism and other neurodevelopmental disorders that share similar cognitive, affective and social impairments.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

100000

Current Award Period

Current Award Period

2010-2013

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SF. Launch randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes in each of the following groups: o Five trials in infants and toddlers by 2013. IACC Recommended Budget: $30,000,000 over 5 years. o Three trials in school-aged children and/or adolescents by 2013. IACC Recommended Budget: $18,000,000 over 5 years. o Three trials in adults by 2014. IACC Recommended Budget: $18,000,000 over 5 years.

Project Link

Project Link

Evidence-based cognitive rehabilitation to improve functional outcomes for young adults with autism spectrum disorders (External web link)

Institution

Institution

University of Pittsburgh

State/Country

State/Country

Pennsylvania

Project Number

Project Number

5703

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Evidence-based cognitive rehabilitation to improve functional outcomes for young adults with autism spectrum disorders | 100000 | 2010 | 5703
Evidence-based cognitive rehabilitation to improve functional outcomes for young adults with autism spectrum disorders | 100000 | 2012 | 5703
Evidence-based cognitive rehabilitation to improve functional outcomes for young adults with autism spectrum disorders | 0 | 2013 | 5703

 
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