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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

MRI study of brain development in school age children with autism

Principal Investigator

Principal Investigator

Hazlett, Heather Cody

Description

Description

Dr. Hazlett's research team at University of North Carolina (UNC) has developed image processing tools specifically designed for highly-efficient, reliable, and valid processing of pediatric magnetic resonance imaging (MRI) data. Their early results from a longitudinal MRI study of brain development demonstrate generalized enlargement of white and gray matter volume in cerebral cortex in autistic individuals at age 2 yrs. This study will track brain development using MRI/DTI (diffusion tensor imaging) scans in 6-10 year olds with autism and controls who have already participated in the longitudinal MRI study of brain development. Forty-two children with autism who have been scanned at ages 2 and 4 will be rescanned at age 6-10. Controls will include typically-developing children and a small subset of children with developmental delay. This study will provide more definitive information about the trajectory of brain growth (regions, tissues, structures, and fiber tracts) as measured on MRI and DTI. Additionally, Dr. Hazlett will be able to explore behavioral features associated with social cognition and ritualistic repetitive behaviors in an in-depth manner now that the children are older (6-10 years old), which may provide important insights into the development of neurobiological mechanisms and behavioral phenotypes in autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

126978

Current Award Period

Current Award Period

2008-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2LA. Complete a large-scale, multi-disciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people by 2020. IACC Recommended Budget: $126,200,000 over 12 years.

Project Link

Project Link

MRI study of brain development in school age children with autism (External web link)

Institution

Institution

University of North Carolina at Chapel Hill

State/Country

State/Country

North Carolina

Project Number

Project Number

2099

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

MRI study of brain development in school age children with autism | 127479 | 2012 | 2099

 
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