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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

UC Davis Center for Children's Environmental Health (CCEH) (supplement)

Principal Investigator

Principal Investigator

Pessah, Isaac

Description

Description

This is a supplement to project 5P01ES011269. The Epidemiology Project of the University of California-Davis Center for Children's Environmental Health (CCEH) will build upon its discovery of immunologic and molecular biomarkers specific to children with autism found in 2-5 year olds enrolled in the CHARGE (Childhood Autism Risks from Genetics and Environment) Study. As one of three interrelated research projects, this study will assess the stability of these immunologic markers over time. It will also test whether children with autism can be distinguished from those without autism by markers of immune dysregulation (at birth as well as post-diagnosis) and by prenatal, immunologically relevant events and exposures. The study aims to determine if children with and without autism differ with regard to exposures, body burdens, and excretion of xenobiotics, including metals, pesticides, and other pollutants (i.e., PBDE's). The transcriptional genomic profiles of children with and without autism will also be analyzed. Finally, a study tracking women at high risk for giving birth to a child with autism will follow them from early pregnancy until the child is three years old. The overall goal of the project is to determine early predictors of autism, whether they be immunologic, genomic, or environmental.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

130000

Current Award Period

Current Award Period

2011-2013

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LD. Support ancillary studies within one or more large-scale, population-based surveillance and epidemiological studies, including U.S. populations, to collect data on environmental factors during preconception, and during prenatal and early postnatal development, as well as genetic data, that could be pooled (as needed), to analyze targets for potential gene/environment interactions by 2015. IACC Recommended Budget: $44,400,000 over 5 years.

Project Link

Project Link

UC Davis Center for Children's Environmental Health (CCEH) (supplement) (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

3P01ES011269-10S3

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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