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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The pathogenesis of autism: Maternal antibody exposure in the fetal brain

Principal Investigator

Principal Investigator

Diamond, Betty

Description

Description

There is abundant evidence that autism occurs in families with evidence of autoimmunity. There is also evidence that mothers of an autistic child may have antibodies that react with brain tissue and even evidence that these antibodies, when given to pregnant mice or pregnant monkeys, cause behaviors in the offspring analogous to aspects of autism spectrum disorders (ASD). The investigators will explore the role of maternal antibodies in ASD, identifying maternal sera with anti-brain antibodies, determining if these antibodies can cause brain pathology and neurologic abnormalities in mice exposed to them during pregnancy, characterizing the brain antigen(s) recognized by the antibodies, and assessing how frequently these antibodies are present in mothers of an autistic child. This group will also examine children born to mothers with particular maternal antibodies and examine the relationship between these circulating antibodies and autism behaviors in the children.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

93500

Current Award Period

Current Award Period

2008-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

The pathogenesis of autism: Maternal antibody exposure in the fetal brain (External web link)

Institution

Institution

The Feinstein Institute for Medical Research

State/Country

State/Country

New York

Project Number

Project Number

4741

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The pathogenesis of autism: Maternal antibody exposure in the fetal brain | 90173 | 2010 | 4741
The pathogenesis of autism: Maternal antibody exposure in the fetal brain | 0 | 2009 | 4741
The pathogenesis of autism: Maternal antibody exposure in the fetal brain | 110000 | 2008 | 4741

 
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