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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism

Principal Investigator

Principal Investigator

Ponzio, Nicholas

Description

Description

One theme that emerges from clinical and experimental studies in autism spectrum disorders (ASD) is inflammation and autoimmunity in individuals with ASD and their families. Dr. Ponzio and his colleagues propose to use well-documented experimental models of ASD to test the hypothesis that stimulation of the maternal immune system during pregnancy alters the normal proportions of newly discovered populations of lymphocytes known as T Helper 17 (TH17) cells and T regulatory (Treg) cells, the balance of which may be responsible for determining whether or not the observed neuroinflammation in ASD occurs. Activation of specific types of lymphocytes during an immune response causes secretion of proteins (known as cytokines) that can induce inflammation. If this occurs during pregnancy, these cytokines may cross the placenta, enter the fetus, and influence neural development and cause immunological outcomes and ASD-like behavior patterns in the offspring. This experiment will examine different mechanisms by which cytokine secretions may mediate neural development, including whether or not they alter the placenta, whether they can enter fetal tissues, and if they promote differentiation of immune cells which alter the neuroinflammatory process.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

93500

Current Award Period

Current Award Period

2008-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Link

Project Link

Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism (External web link)

Institution

Institution

University of Medicine & Dentistry of New Jersey

State/Country

State/Country

New Jersey

Project Number

Project Number

4934

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism | 93500 | 2010 | 4934
Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism | 110000 | 2008 | 2545
Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism | 127499 | 2009 | 2545
Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism | 0 | 2012 | 4934

 
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