Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

In-vivo imaging of neuronal structure and function in a reversible mouse model for autism.

Principal Investigator

Principal Investigator

Ash, Ryan

Description

Description

Overexpression of the transcriptional regulator MECP2 causes autistic features and abnormal neuronal structure and function in humans and mice. We hypothesize that the severity of cortical dysfunction mediated by MECP2 overexpression depends on the overall maturity of the brain, such that overexpression in an embryonic or early postnatal brain will have harsher consequences than overexpression in a fully matured adult brain. We also hypothesize that the damage to cortical circuits mediated by MECP2 overexpression are cumulative and become more entrenched with time, so reversal of MECP2 overexpression in the early postnatal period will more fully ameliorate disease phenotypes than reversal in the adult. To test these hypotheses, we will study autistic behaviors and motor cortical circuits in mice that overexpress MECP2 at different stages of development. We will then assess the entrenchedness of disease phenotypes by reversing gene overexpression in 1) a developing postnatal brain and 2) a fully matured adult brain. The results will help elucidate mechanisms of cortical circuit dysfunction in autism. Moreover, the data have that potential to provide proof of principle of the degree to which MECP2 duplication syndrome and autism are reversible, as well as information essential to the design of therapies and therapeutic regimens for such autistic spectrum disorders.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

28000

Current Award Period

Current Award Period

2010-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. (External web link)

Institution

Institution

Baylor College of Medicine

State/Country

State/Country

Texas

Project Number

Project Number

7053

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. | 28000 | 2010 | 7053
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. | 0 | 2012 | 7053

 
Back to Top