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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Trial of a glutamate antagonist in the treatment of OCD and autistic disorders

Principal Investigator

Principal Investigator

Swedo, Susan

Description

Description

Riluzole, a glutamate antagonist, reduces compulsions (including repetitive behavior) in adults with obsessive-compulsive disorder (OCD). Given the close similarity between symptoms in childhood-onset OCD and the frequency with which OCD is present as a co-occuring condition in autism spectrum disorder (ASD), it is postulated that medications which reduce OCD symptoms might also improve the repetitive behaviors and fixated interests of ASD. Preliminary data will be collected on riluzole efficacy and safety in children and adolescents with co-occurring conditions of ASD and OCD. Additionally, a study of the neurochemical effects of riluzole treatment is underway in which children and adolescents will undergo a magnetic resonance spectroscopy (MRS) scan (similar to a magnetic resonance imaging (MRI) scan) before starting treatment with riluzole and during treatment. Changes in brain concentrations of glutamate and related chemicals will be assessed and compared with symptom severity and degree of treatment response.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

352969

Current Award Period

Current Award Period

Ongoing

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4LA. Complete at least three randomized controlled trials on medications targeting core symptoms in people with ASD of all ages by 2014. IACC Recommended Budget: $22,200,000 over 5 years.

Project Link

Project Link

Trial of a glutamate antagonist in the treatment of OCD and autistic disorders (External web link)

Institution

Institution

National Institutes of Health

State/Country

State/Country

Maryland

Project Number

Project Number

1ZIAMH002913-04

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Trial of a glutamate antagonist in the treatment of OCD and autistic disorders | 33959 | 2012 | 1ZIAMH002913-05

 
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