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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Cell speciflc genomic imprinfing during cortical development and in mouse models

Principal Investigator

Principal Investigator

Dulac, Catherine

Description

Description

Genomic imprinting results in the preferential expression of the paternally or maternally inherited allele of certain genes. This epigenetic regulation of gene expression is essential for normal brain development, and defects in imprinted genes have been implicated in autism. We have discovered over 1300 new imprinted loci in the adult and developing brain and have demonstrated that the repertoires of imprinted genes in the developing brain and adult male and female cortex are different. This project aims to unravel parental bias of gene expression in a genetically defined cortical cell population, the pan/albumin (PV) positive inhibitory interneurons that are thought to play major roles in the maturation of cortical circuits, and to be affected in various mental disorders.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

312559

Current Award Period

Current Award Period

2011-2016

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SJ. Support at least three studies that focus on the role of epigenetics in the etiology of ASD, including studies that include assays to measure DNA methylations and histone modifications and those exploring how exposures may act on maternal or paternal genomes via epigenetic mechanisms to alter gene expression, by 2012. IACC Recommended Budget: $20,000,000 over 5 years.

Project Link

Project Link

Cell speciflc genomic imprinfing during cortical development and in mouse models (External web link)

Institution

Institution

Harvard University

State/Country

State/Country

Massachusetts

Project Number

Project Number

1P50MH094271-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Cell speciflc genomic imprinfing during cortical development and in mouse models | 328975 | 2012 | 5P50MH094271-02

 
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