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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Emergence and stability of autism in fragile X syndrome

Principal Investigator

Principal Investigator

Roberts, Jane

Description

Description

Fragile X syndrome (FXS) is the leading genetic cause of autism, and both FXS and the FMR1 premutation (FXpm) are highly associated with autism. This project aims to identify early indicators of autism in FXS or FXpm in a longitudinal prospective study of the early autism features in infants with FXS and FXpm at 9, 12, and 24 months. This project will use a combined behavioral and biomarker approach focused on autistic behavior as a continuum rather than rigid diagnostic categories.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

358000

Current Award Period

Current Award Period

2011-2016

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Emergence and stability of autism in fragile X syndrome (External web link)

Institution

Institution

University of South Carolina

State/Country

State/Country

South Carolina

Project Number

Project Number

1R01MH090194-01A1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Emergence and stability of autism in fragile X syndrome | 358000 | 2012 | 5R01MH090194-02
Emergence and stability of autism in fragile X syndrome (supplement) | 87314 | 2012 | 3R01MH090194-02S1

 
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