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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Electrophysiological signatures of language impairment in autism spectrum disorder

Principal Investigator

Principal Investigator

Roberts, Timothy

Description

Description

The clinical profiles of several developmental disorders, including autism spectrum disorders (ASD), involve varying degrees of co-occurring language impairment (LI). The underlying neuronal deficits for LI are numerous and may include deficits in perception, processing, and/or cognition. Current understanding of how a deficit at each or any of these levels might relate to LI is not sufficiently sophisticated to distinguish neuronally-based subtypes of LI. In this study, researchers seek to identify electrophysiological signatures, or endophenotypes, associated with the neural correlates of language impairment in ASD. Specifically, a population of children with autism spectrum disorders (both with and without concomitant LI) will be investigated to find neuronal characteristics associated with autism per se, with LI per se, and with both in combination. If endophenotypes to language impairment can be found, individuals could be sub-typed, or grouped together by the nature of their underlying neuronal deficit, which may aid greatly in addressing the heterogeneity of ASD and in the design of future interventions appropriately targeted to varying ASD subtypes.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

344521

Current Award Period

Current Award Period

2007-2013

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.

Project Link

Project Link

Electrophysiological signatures of language impairment in autism spectrum disorder (External web link)

Institution

Institution

University of Pennsylvania/Children's Hospital of Philadelphia

State/Country

State/Country

Pennsylvania

Project Number

Project Number

5R01DC008871-05

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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