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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Mouse models of the neuropathology of tuberous sclerosis complex

Principal Investigator

Principal Investigator

Gambello, Michael

Description

Description

Tuberous sclerosis complex (TSC) is genetic disorder affecting approximately 1/6000 individuals, causing brain lesions that are associated with seizures, autism, and other developmental disabilities. Remarkably, little is known about the pathogenesis of these lesions or how they lead to developmental disabilities. The goal of this research project is to use mouse genetics to understand the developmental abnormalities that lead to the brain lesions of the genetic disease tuberous sclerosis complex (TSC). Well characterized models will establish a foundation for the testing of future targeted therapies and establish developmental neurobiologic differences between subsets of patients with TSC.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

253177

Current Award Period

Current Award Period

2007-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Mouse models of the neuropathology of tuberous sclerosis complex (External web link)

Institution

Institution

University of Texas Health Science Center at Houston

State/Country

State/Country

Texas

Project Number

Project Number

5R01NS060804-05

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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