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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Double masked placebo controlled trial of cholesterol in hypocholesterolemic ASD 

Principal Investigator

Principal Investigator

Tierney, Elaine

Description

Description

Previous work from the Tierney laboratory has suggested that some individuals with autism spectrum disorders (ASDs) have very low blood cholesterol levels. Low cholesterol may be an important marker for subtypes of ASD; it may also play a role in causing some types of ASD, as cholesterol is known to be important for several aspects of brain development. The present study will test the response of individuals with ASD and low cholesterol to increased cholesterol in their diets. A randomized sample of youths with ASD will be given supplementary cholesterol over a 12 week period, and the effects of the treatment on behavior, communication, and other features of autism will be measured and compared to a group given placebo. This research will help to determine whether adding cholesterol to the diet can improve behavioral problems seen in individuals with ASD and low cholesterol.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

253653

Current Award Period

Current Award Period

2009-2012

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SC. Test safety and efficacy of at least five widely used interventions (e.g., nutrition, medications, assisted technologies, sensory integration, medical procedures) that have not been rigorously studied for use in ASD by 2012. IACC Recommended Budget: $27,800,000 over 5 years.

Project Link

Project Link

Double masked placebo controlled trial of cholesterol in hypocholesterolemic ASD  (External web link)

Institution

Institution

Kennedy Krieger Institute

State/Country

State/Country

Maryland

Project Number

Project Number

2990

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Double masked placebo controlled trial of cholesterol in hypocholesterolemic ASD  | 0 | 2012 | 2990

 
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