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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Augmentation of the cholinergic system in fragile X syndrome: a double-blind placebo study

Principal Investigator

Principal Investigator

Reiss, Allan

Description

Description

Fragile X syndrome (FraX, also FXS) is the most common known heritable cause of human intellectual disability. Though recent research has revealed much about the genetic and neurobiological bases of FraX, knowledge about specific and effective treatments for affected individuals is lacking. Based on information from both human and animal studies, one cause of intellectual disability in FraX may be related to deficits in a particular brain neurotransmitter system (the "cholinergic" system). Thus, this study will use a specific medication, donepezil, to augment the cholinergic system in adolescents affected by FraX. If found to be effective, the knowledge generated by this research may also be relevant to other developmental disorders that share common disease pathways with FraX.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

237600

Current Award Period

Current Award Period

2009-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Augmentation of the cholinergic system in fragile X syndrome: a double-blind placebo study (External web link)

Institution

Institution

Stanford University

State/Country

State/Country

California

Project Number

Project Number

5R34MH085899-03

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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