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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Center: Risk and protective factors in the development of associated symptoms in autism

Principal Investigator

Principal Investigator

Estes, Annette

Description

Description

This grant provides support for an NIH Autism Center of Excellence (ACE). This project examines the interaction between genetic and child phenotypic risk factors and family processes in determining outcome in autism. Outcome will be examined not only in terms of core symptoms but also in terms of associated symptoms, including repetitive and stereotyped behaviors, hyperactivity, and externalizing and internalizing behaviors. First, in a prospective longitudinal cohort study of children who are transitioning into adolescence, the study will investigate the role of genetic, child phenotypic, and family risk and protective factors in development of associated symptoms. Second, in a younger longitudinal cohort, a follow-up study of a randomized, controlled trial of early intensive behavioral intervention to examine the long term effects on both core and associated symptoms will be conducted. The identification of risk and protective factors related to long term outcome, including the development of associated symptoms, will inform critical targets for therapeutic intervention for affected children and families.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

168117

Current Award Period

Current Award Period

2007-2012

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SF. Launch randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes in each of the following groups: o Five trials in infants and toddlers by 2013. IACC Recommended Budget: $30,000,000 over 5 years. o Three trials in school-aged children and/or adolescents by 2013. IACC Recommended Budget: $18,000,000 over 5 years. o Three trials in adults by 2014. IACC Recommended Budget: $18,000,000 over 5 years.

Project Link

Project Link

ACE Center: Risk and protective factors in the development of associated symptoms in autism (External web link)

Institution

Institution

University of Washington

State/Country

State/Country

Washington

Project Number

Project Number

5P50HD055782-05

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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