In this study, mouse models of autism spectrum disorders will be used to investigate the effects of drug treatment on motivated behaviors. To model behavioral therapy in mice, intracranial electrical stimulation (ICSS) will be used. ICSS measures motivated behaviors: an electrode implanted in a specific region of a mouse's brain provides a "reward" sensation when a lever is pressed. Animals will self-stimulate by pressing the lever, and the administration of drugs known to affect the reward pathway can modulate this response. In this study, researchers will use ICSS to study motivated behaviors in three commonly used mouse models of autism (fragile X syndrome, Rett syndrome, and Angelman syndrome). These mice will be treated with drugs which are known to affect reward pathways and drugs which are commonly used to treat autism, such as dopamine-blocking neuroleptics. These experiments will determine whether these drugs enhance or impair motivated behaviors in animals with autistic behaviors.