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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders 

Principal Investigator

Principal Investigator

Malanga, C.J.

Description

Description

In this study, mouse models of autism spectrum disorders will be used to investigate the effects of drug treatment on motivated behaviors. To model behavioral therapy in mice, intracranial electrical stimulation (ICSS) will be used. ICSS measures motivated behaviors: an electrode implanted in a specific region of a mouse's brain provides a "reward" sensation when a lever is pressed. Animals will self-stimulate by pressing the lever, and the administration of drugs known to affect the reward pathway can modulate this response. In this study, researchers will use ICSS to study motivated behaviors in three commonly used mouse models of autism (fragile X syndrome, Rett syndrome, and Angelman syndrome). These mice will be treated with drugs which are known to affect reward pathways and drugs which are commonly used to treat autism, such as dopamine-blocking neuroleptics. These experiments will determine whether these drugs enhance or impair motivated behaviors in animals with autistic behaviors.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

228965

Current Award Period

Current Award Period

2008-2011

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders  (External web link)

Institution

Institution

University of North Carolina School of Medicine 

State/Country

State/Country

North Carolina

Project Number

Project Number

2670

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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