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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Network: A longitudinal MRI study of infants at risk for autism

Principal Investigator

Principal Investigator

Piven, Joseph

Description

Description

This study is part of an Autism Centers of Excellence (ACE) Network. Multiple lines of converging evidence (from magnetic resonance imaging (MRI), post-mortem, and head circumference studies) document brain enlargement in autism, with some evidence of this within the first year of life. New imaging methods provide highly detailed MRI data and are well suited for rapid scanning of very young children. In addition, new behavioral assessment tools enable the efficient screening and detection, at 12 months, of infants who are likely to meet criteria for autism at age two. In this study, these new methods will be used to conduct a longitudinal MRI/diffusion tensor imaging (DTI) study of six month old infant sibs of autistic individuals, with follow-up at 12 and 24 months of age. This research will provide new information about the trajectory of early postnatal brain overgrowth (regions, tissues, structures, and fiber tracts), as measured on MRI and DTI, and its potential relationship to clinical features. It may provide insights into developmental brain and behavioral phenotypes, as well as neurobiological mechanisms, that will inform other levels of analysis (e.g., molecular biological studies of this period) during what appears to be a critical period of development in the pathogenesis of autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

3246479

Current Award Period

Current Award Period

2007-2013

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Project Link

Project Link

ACE Network: A longitudinal MRI study of infants at risk for autism (External web link)

Institution

Institution

University of North Carolina at Chapel Hill

State/Country

State/Country

North Carolina

Project Number

Project Number

5R01HD055741-05

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

ACE Network: A longitudinal MRI study of infants at risk for autism | 2619590 | 2012 | 2R01HD055741-06
ACE Network: A longitudinal MRI study of infants at risk for autism (supplement) | 565115 | 2012 | 3R01HD055741-06S1

 
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